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Targeted metabolomic pathway analysis and validation revealed glutamatergic disorder in the prefrontal cortex among the chronic social defeat stress mice model of depression

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Therefore, when extrapolating the experimental results of a liver microsome incubation system to the human body, we must be extra cautious to avoid misleading drug research and development decisions ( 4.3.2 Liver cytosol After ultracentrifugation, the supernatant of the liver cytosol was used to remove all organelles (Figure 4A), and the granules contained mainly phase II metabolic enzymes and fewer phase I metabolic enzymes

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